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Glyburide and metformin may make your skin sensitive to sunlight.

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Insulin should be considered if the patient has very high FPG, is symptomatic, or if blood glucose is poorly controlled on dual or triple therapy.

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What I have realized is that the focus should be reducing your fasting insulin levels, whereas your focus is, like many others, on keeping your "blood sugars in line".

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By increasing insulin sensitivity and decreasing the ovarian production of male hormones, metformin stabilizes hormone levels, improves menstrual regularity and possibly improves ovulation and fertility in women with PCOS.

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Metformin has not been linked to serum enzyme elevations during therapy and is an exceeding rare cause of idiosyncratic clinically apparent acute liver injury.

Other AMPK-independent effects include inhibition of the serine-protein kinase ATM and reduction of ROS levels, which are produced by mitochondrial complex I and confer mutagenesis risk.

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If your blood sugars are normal, I would suggest cutting your carbs down to a level you can live with for the next ten years or more, rather than a crash diet like Atkins that you can stick to for a month or two and then abandon (which is what most people do.

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These doses are both approximately four times the maximum recommended human daily dose of 2000 mg based on body surface area comparisons.

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All of these metformin-dependent effects in mouse xenografts are associated with selective killing of CSCs in the tumors.

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